• Due to complexity and differentiation, vaginal microbiota is only the second to that of the intestine and it plays a key-role in the female genital health. It changes several times throughout their lives, sometimes in a physiological manner (as in the case of the arrival of menarche, during pregnancy or menopause) other times as a result of external factors such as taking medications, the use of inadequate products for intimate hygiene, due to incorrect lifestyle, especially in terms of nutrition, or trivially because of excessive sexual activity. As it is known, the most important species of the vaginal flora are lactobacilli, whose taxonomy has expanded considerably thanks to the use of typing methods based on genome. They represent a biological barrier to the easy entry point protection for pathogens, even more so when you consider the proximity of anal orifice from which can begin colonization. The protective action is realized above all by lactic acid biosynthesis and physiological acidification of mucous and secretions, for anti-adhesive effect that prevents the attack and proliferation of other species, thanks to the release of autogenous cytotoxic factors (on all the hydrogen peroxide and bacteriocins) and finally by stimulating local immune defenses of the host. Appropriately selected strains of L. rhamnosus, L. salivarius and L. reuterii have shown to play a probiotic role in the urogenital district both when they are administered orally and after local application (Marelli G. et al., 2004) protecting women from episodes of recurrent vaginitis and other infections of the lower urinary tract. Some clinical trials with an experimental design complies to the guidelines outlined by EFSA conducted on well characterized probiotic strains of L. reuterii and L. rhamnosus in bacterial vaginitis have highlighted the superiority of treatment with probiotics alone than with just metronidazole (Anukam et al., 2006, Mastromarino et al. 2009). Similar results were obtained in the recurrent vulvovaginitis from Candida albicans (Hilton et al 1992, Reid et al. 2001).


    The vaginal balance mix of Nutraceutica is a 100% Italian product made with selected strains of L. salivarius and L. reuterii that produce high amounts of  hydrogen peroxide and  L. acidophilus, homo-fermenting, to restore the physiological pH in the conditions in which it is altered. In total it contains 50 billion CFU / g and is suitable for formulating dietary supplements aimed at restoring the vaginal microbiota after antibiotic therapy or with estrogen-progestin, to prevent vulvovaginitis of fungal and bacterial basis and as a complementary treatment for prevention of lower urinary tract infections. The vaginal balance mix of Nutraceutica can also be included in the formulation of preparations for topical use such as medical and surgical devices.